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Taking advantage of the wealth of information generated by the "new biology" of the Human Genome Project, DOE's Life Sciences Division is funding $16 million in projects that focus on high-throughput approaches to solving complex biological problems related to DOE's diverse missions. The research, which is taking place at 5 DOE national laboratories and 13 universities and research institutions, will address unresolved issues in the following 4 major areas.
Biochemical Potential of Microbes
($2 million). Researchers seek to develop methods to decode the complete genomes of microbes more rapidly, identify potentially useful microbes, and explore their potential for energy production and use and for environmental cleanup.
Health Risks from Low-Level Exposures to Radiation and Other Energy-Related By-Products
($6 million). New information will be useful in the ongoing development of federal health-risk policies that protect workers and the public from radiation and environmental pollutants, including those at DOE sites.
"Engineered" Biomolecules for Use in Energy Production, Environmental Cleanup, Drug Design, and Industry
($2 million). Developing methods to rapidly determine the structure of large numbers of proteins will contribute to capabilities for designing biomolecules such as enzymes, antibodies, and other proteins for these applications.
New Genetic Information from Mice, Yeast, and Fruit Flies for Understanding Human Gene Functions More Quickly
($6 million). This research will contribute to more accurate disease prediction and diagnosis and the design of drug therapies tailored to an individual's genetic makeup.
DOE's life sciences research program began more than 50 years ago to study the health effects of radiation, initially focusing on epidemiological studies of exposed people and genetic studies in animals. Nearly 15 years ago, DOE started planning its Human Genome Program to obtain DNA sequencing and analysis technologies and information at the genetic level regarding the effects of radiation and energy production on biological systems. In seeking to translate genomics for applications in diverse fields, DOE is helping to usher in what has been called the "biology century." |
| Author: Aaron Hall |
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